Asimilobine ( —— )

产品货号. M21801 CAS No. 6871-21-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Asimilobine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Asimilobine 是一种从木兰植物中分离出来的阿朴啡异喹啉生物碱。阿西洛滨是一种多巴胺生物合成抑制剂和血清素受体拮抗剂。阿西洛滨具有抗疟和抗癌活性。
产品描述

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity.
体外实验

Asimilobine (0.05-0.2 μM; for 24 h) shows a significant inhibition of intracellular dopamine levels in a concentration-dependent manner with an IC50 value of 0.13 μM. Asimilobine (0.15 μM) inhibits tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities at 24 h. Asimilobine also decreases TH mRNA levels and intracellular cyclic AMP levels.
体内实验

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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计算器

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